MAP Master Amino Acid Pattern®
Since 1992
About MAP®
DESCRIPTION
MAP® is a dietary protein substitute that provides the MAP Master Amino Acid Pattern®, described in U.S. Patent No. 5,132,113, a unique pattern of essential amino acids in a highly purified, free, crystalline form. After oral ingestion, MAP® is rapidly utilized. MAP® does not require the aid of peptidases and therefore is absorbed within 23 minutes through the first 100 cm of functional small intestine. MAP® does not provide any fecal residue. MAP® is amphoteric. MAP® is supplied in tablets of 1,000 mg for oral administration. Each tablet of MAP® contains only the active ingredient MAP Master Amino acid Pattern®. MAP® contains no inactive ingredients.
COMPOSITION
MAP® contains the MAP Master Amino Acid Pattern®, described in U.S. Patent No. 5,132,113, a unique pattern of essential amino acids in a highly purified, free, crystalline form.
CLINICAL STUDIES
The results of comparative, double-blind, triple- and quintuple-crossover Net Nitrogen Utilization® (NNU®) clinical studies have shown that the subjects, while taking MAP®, as a dietary protein substitute, achieved a body’s 99% NNU®. This means that 99% of MAP®'s constituent amino acids followed the anabolic pathway, thus acting as precursor of body’s protein synthesis (BPS). By comparison, the most nutritious dietary proteins provide an average of only 32% NNU®. Hence, MAP® is more nutritious than dietary proteins. This has been confirmed by the fact that during the studies, each subject body’s nitrogen balance was maintained in equilibrium by taking MAP® as a sole and total substitute of dietary proteins in a dosage of only 400 mg/kg/day (ideal weight) which provided less than 2 kcal/day (1 g MAP® = 0.04 kcal). The studies results have also shown that 1% of MAP®'s constituent amino acids followed the catabolic pathway, thus releasing only 1% of nitrogen catabolites and energy. By comparison dietary proteins release an average of 68% nitrogen catabolites and energy. These facts evidence that MAP® is safer than dietary proteins and provides the lowest amount of energy in comparison to any dietary protein.
To illustrate: when a dietary protein is digested, it releases its constituent amino acids into the small intestine where they are absorbed. Then, those amino acids can follow either the anabolic pathway or the catabolic pathway (Fig. I).
Figure 1. Dietary Protein Metabolism
To illustrate: when a dietary protein is digested, it releases its constituent amino acids into the small intestine where they are absorbed. Then, those amino acids can follow either the anabolic pathway (build-up) or the catabolic (breakdown) pathway.
Figure 1. Dietary Protein Metabolism
To illustrate: when a dietary protein is digested, it releases its constituent amino acids into the small intestine where they are absorbed. Then, those amino acids can follow either the anabolic pathway (build-up) or the catabolic (breakdown) pathway.
Figure II. The Protein Metabolism Anabolic Pathway
When dietary amino acids follow the anabolic pathway, they act as precursors for the body’s protein synthesis, thus becoming the body’s constituent proteins. Throughout the anabolic pathway, amino acids do not release any nitrogen catabolites or energy.
Figure II. The Protein Metabolism Anabolic Pathway
When dietary amino acids follow the anabolic pathway, they act as precursors for the body’s protein synthesis, thus becoming the body’s constituent proteins. Throughout the anabolic pathway, amino acids do not release any nitrogen catabolites or energy.
Figure III. The Protein Metabolism Catabolic Pathway
On the other hand, when dietary amino acids follow the catabolic pathway, they act only as a source of energy and not as precursors of Body’s Proteins Synthesis (BPS). Throughout the catabolic pathway, amino acids do release nitrogen catabolites (toxic metabolic waste) and energy.
Figure III. The Protein Metabolism Catabolic Pathway
On the other hand, when dietary amino acids follow the catabolic pathway, they act only as a source of energy and not as precursors of Body’s Proteins Synthesis (BPS). Throughout the catabolic pathway, amino acids do release nitrogen catabolites ( toxic metabolic waste) and energy
INDICATIONS AND USAGE
MAP® is indicated as a safe and effective substitute for dietary proteins.
| Characteristics | MAP® | Dietary Proteins | Dietary Protein Supplements |
|---|---|---|---|
| Net Nitrogen Utilization® (NNU®) for Body Protein Synthesis (BPS) | 99% | 32% (average) | 16% (average) |
| Digestion Time | 23 min | 3-6 hours (6-12 times longer) | 3-6 hours (6-12 times longer) |
| BPS/Time (NNU®/min) | 99% NNU®/ 23 min | 24-48 times lower | 48-96 times lower |
| Released Nitrogen Catabolites | 1% | 68% (average) | 84% (average) |
| Energy | 0.04 kcal/g | 4 kcal/g | 4 kcal/g |
| Fecal residue | Absent | Present | Present |
| Contraindications | None | Renal Failure or Hepatic Failure | Renal Failure or Hepatic Failure |
| Adverse Reactions | None | Food Sensitivities | Food Sensitivities |
| Refrigeration | Not Needed | Needed | N/A |
ADVERSE REACTIONS
No adverse reactions have been reported.
OVERDOSAGE
No adverse reactions have been reported.
DOSAGE AND ADMINISTRATION
MAP® should be administered with food. MAP® in a dosage of 400mg/kg/day (ideal weight) has been shown to be adequate as a sole and total substitute of dietary proteins to maintain the body’s nitrogen balance in equilibrium. To calculate the MAP Master Amino Acid Pattern® dosage necessary to substitute dietary proteins, apply the following:
MAP® dosage = (Dietary Protein x 0.4) g
For instance, to calculate the dosage of MAP® necessary to substitute 10 g of dietary proteins, proceed as follows:
- MAP® dosage = (Dietary Proteins x 0.4) g
- MAP® dosage = (10 x 0.4) g
- MAP® dosage = 4 g
Therefore, 4 g (4 tablets) of MAP® provide a body’s protein synthesis (BPS) equivalent to that provided by at least 10 g of the most nutritious dietary protein.
If administering more than 10 tablets per day, increase dosage gradually. (No more than 10 tablets should be administered within a two hour period.)
SUPPLY INFORMATION
MAP® is available in bottles of 120 tablets of 1,000 mg, for oral administration.